S. Sprecher publications

(download as a pdf)

 

2022

 

Martinez P, Ballarin L, Ereskovsky  AV, Gazave E, Hobmayer B, Manni L, Rottinger  S, Sprecher SG, Tiozzo S, Varela-Coelho A and Rinkevich B

Articulating the “stem cell niche” paradigm through the lens of non-model aquatic invertebrates

BMC Biology 20 (1), 1-18

IF: 5.9


Komarov N and Sprecher SG

The chemosensory system of the Drosophila larva: an overview of current understanding

Fly 16 (1), 1-12

IF: 2.2

 

2021

 

Maier GL, Komarov N, Meyenhofer F, Kwon JY and Sprecher SG

Taste sensing and sugar detection mechanisms in Drosophila larval primary taste center

eLife 8, e 67844

IF: 7.6


Kaldun JC, Lone SR, Humbert Camps AM, C Fritsch C, Widmer YF, Stein JV, Tomchik SM and Sprecher SG.

Dopamine, sleep, and neuronal excitability modulate amyloid-β–mediated forgetting in Drosophila

PLoS Biology 19 (10), e3001412

IF: 8.1

AK Mishra, C Fritsch, R Voutev, RS Mann, SG Sprecher

Homothorax Controls a Binary Rhodopsin Switch in Drosophila Ocelli

PLoS Genetics. 2021 Jul 27;17(7):e1009460.IF: 5.5

IF: 5.5


Chang Z, Widmer YF, Diegelmann S, Petrovici M, Sprecher* SG and Senn W*

Predictive olfactory learning in Drosophila

Scientific Reports in press

* co-corresponding authors

IF: 4.1


Brunet Avalos C and Sprecher SG

Single-Cell Transcriptomic Reveals Dual and Multi-Transmitter Use in Neurons Across Metazoans

Frontiers In Molecular Neuroscience. 2021; 14: 623148.

IF: 5.1


Duruz J, Kaltenrieder C, Ladurner P, Bruggmann R, Martìnez P and Sprecher SG

Acoel single-cell transcriptomics: cell-type analysis of a deep branching bilaterian

Molecular Biology and Evolution 2021 May 4;38(5):1888-1904

IF: 11.1

 

 

2020

 

Asirim E, Maier GL, Humberg TH, Sprecher SG

Circadian and Genetic Modulation of Visually-Guided Navigation in Drosophila Larvae

Scientific Reports 10.1038/s41598-020-59614

IF: 4.1


Fritsch C and Sprecher SG

CRISPR/Cas9 Genome Editing to Study Nervous System Development in Drosophila

Methods Mol Biol. 2020;2047:161-189

IF: 10.7

Perea-Atienza E, Gavilán B, Sprecher SG, Martinez P.

Immunostaining and In Situ Hybridization of the Developing Acoel Nervous System

Methods Mol Biol. 2020;2047:59-80. 

IF: 10.7

Choi J, Yu S, Choi MS, Jang S, Han IJ, Maier GL, Sprecher SG*, Kwon JY.*

Cellular Basis of Bitter-Driven Aversive Behaviors in Drosophila Larva.

eNeuro. 2020 Apr 24;7(2):ENEURO.0510-19.2020

* co-corresponding authors

IF: 3.5

 

 

2019

 

Brunet Avalos C, Maier GL, Bruggmann R and Sprecher SG

Single cell transcriptome atlas of the Drosophila larval brain

eLife 8, e 50354

IF: 7.6


Bo Q, Humberg TH, Kim A, Kim H, Short J, Diao F, White BH, Sprecher SG, Yuan Q

Temporal control of inhibition via muscarinic acetylcholine receptor signaling generates ON and OFF selectivity in a simple visual circuit

Nature Communications 2019 Sep 9;10(1):4093.

IF: 12.4


de Andres-Bragado L and Sprecher SG.                                                             

Mechanisms of vision in the fruit fly.                                                                                  

Curr Opin Insect Sci. 2019 Jun 27;36:25-32. doi: 10.1016

 

Fritsch C, Bernardo-Garcia FJ, Humberg TH, Mishra AK, Miellet S, Almeida S, Frochaux MV, Deplancke B, Huber A and Sprecher SG.                                   

Multilevel regulation of the glass locus during Drosophila eye development.                  

PLoS Genetics. 2019 Jul 12;15(7):e1008269. doi: 10.1371

 

Kaldun JC and Sprecher SG.  

Initiated by CREB: Resolving Gene Regulatory Programs in Learning and Memory   

Bioessays 2019 Aug;41(8):e1900045. doi: 10.1002

 

Javier Bernardo-Garcia, Maryam Syed, Gaspar Jekely, Simon G Sprecher     

Glass confers rhabdomeric photoreceptor identity in Drosophila, but not across all metazoans 

EvoDevo 2019 Mar 5;10:4. doi: 10.1186

 

Gavilán B, Sprecher SG, Hartenstein V, Martinez P. 

The digestive system of xenacoelomorphs.

Cell Tissue Res. 2019 May 16

 

Hartenstein V, Yuan M, Younossi-Hartenstein A, Karandikar A, Bernardo-Garcia FJ, Sprecher SG, Knust E.              

Serial electron microscopic reconstruction of the drosophila larval eye: Photoreceptors with a rudimentary rhabdomere of microvillar-like processes. 

Developmental Biology. 2019 May 31. pii: S0012-1606(19)30196-4

 

2018

 

Widmer YF, Fritsch C, Jungo MM, Almeida S, Egger B, Sprecher SG.                     

Multiple neurons encode CrebB dependent appetitive long-term memory in the mushroom body circuit.                                                      

eLife. 2018 Oct 22;7. pii: e39196. doi: 10.7554/eLife.39196.

 

Sánchez-Alcañiz JA, Silbering AF, Croset V, Zappia G, Sivasubramaniam AK, Abuin L, Sahai SY, Münch D, Steck K, Auer TO, Cruchet S, Neagu-Maier GL, Sprecher SG, Ribeiro C, Yapici N, Benton R.

An expression atlas of variant ionotropic glutamate receptors identifies a molecular basis of carbonation sensing.                                     

Nature Communications. 2018 Oct 12;9(1):4252. doi: 10.1038/s41467-018-06453-1.

 

Humberg TH and Sprecher SG 

Two Pairs of Drosophila Central Brain Neurons Mediate Larval Navigational Strategies Based on Temporal Light Information Processing                

Frontiers in Behavioral Neuroscience 2018 Dec.

 

Brauchle M, Bilican A, Eyer C, Bailly X, Martinez P, Ladurner P, Bruggmann R and Sprecher SG. 

Xenacoelomorpha survey reveals that all 11 animal homeobox gene classes were present in the first bilaterians. 

Genome Biology and Evolution, evy170, https://doi.org/10.1093/gbe/evy170

 

de Andres-Bragado L, Mazza C, Senn W, Sprecher SG.

Statistical modelling of navigational decisions based on intensity versus directionality in Drosophila larval phototaxis. 

Scientific Reports. 2018 Jul 26;8(1):11272. doi: 10.1038/s41598-018-29533-0.

 

Widmer YF, Bilican A, Bruggmann R, Sprecher SG. 

Regulators of Long-Term Memory Revealed by Mushroom Body-Specific Gene Expression Profiling in Drosophila melanogaster. 

Genetics. 2018 Aug;209(4):1167-1181. doi: 10.1534/genetics.118.301106.

 

Perea-Atienza E, Sprecher SG, Martínez P.

Characterization of the bHLH family of transcriptional regulators in the acoel S. roscoffensis and their putative role in neurogenesis.

Evodevo. 2018 Mar 29;9:8. doi: 10.1186/s13227-018-0097-y.

 

Mishra AK, F. Bernardo-Garcia J, Fritsch C, Homberg TH, Egger B & Sprecher SG (2018). 

Patterning mechanisms diversify neuroepithelial domains in the Drosophila optic placode.

PLoS Genetics (online: https://doi.org/10.1371/journal.pgen.1007353).

 

Humberg TH, Bruegger P, Afonso B, Zlatic M, Truman JW, Gershow M, Samuel A & Sprecher SG (2018). 

Dedicated photoreceptor pathways in Drosophila larvae mediate navigation by processing either spatial or temporal cues. 

Nature Communications  9: Article number: 1260 (online doi:10.1038/s41467-018-03520-5).

 

Kendroud S, Bohra AA, Kuert PA, Nguyen B, Guillermin O, Sprecher SG, Reichert H, VijayRaghavan K & Hartenstein V (2018).

Structure and development of the subesophageal zone of the Drosophila brain. II. Sensory compartments.

J. Comparative Neurolology 526: 33-58 (online doi: 10.1002/cne.24316).

 

2017

 

Burkhardt P & Sprecher S (2017). 

Evolutionary origin of synapses and neurons–Bridging the gap.

Bioessays 39: 1700024 (doi: 10.1002/bies.201700024).

 

Larderet I, Fritsch PMJ, Gendre N, Neagu-Maier GL, Fetter RD, Schneider-Mizell CM, Truman JW, Zlatic M, Cardona A & Sprecher SG (2017).

Organization of the Drosophila larval visual circuit.

eLife 2017;6:e28387 DOI: 10.7554/eLife.28387.

 

Almeida-Carvalho MJ, Berh D, Braun A, Chen Y, Eichler K, Eschbach C, Fritsch PMJ, Gerber B, Hoyer N, Jiang X, Kleber J, Klämbt C, König C, Louis M, Michels B, Miroschnikow A, Mirth C, Miura D, Niewalda T, Otto N, Paisios E, Pankratz MJ, Petersen M, Ramsperger N, Randel N, Risse B, Saumweber T, Schlegel P, Schleyer M, Soba P, Sprecher SG, Tanimura T, Thum AS, Toshima N, Truman JW, Yarali A & Zlatic M (2017). 

The Ol1mpiad: concordance of behavioural faculties of stage 1 and stage 3 Drosophila larvae. 

Journal of Experimental Biology 220: 2452-2475 (link)

 

Martinez P, Hartenstein V & Sprecher S (2017). 

"Xenacoelomorpha Nervous Systems" In Oxford Research Encyclopedia of Neuroscience (Ed. Sherman M), Oxford University Press, New York (online: DOI: 10.1093/acrefore/9780190264086.013.203).

 

Martinez P, Perea-Atienza E, Gavilán B, Fernandez C & Sprecher S (2017). 

The study of xenacoelomorph nervous systems. Molecular and morphological perspectives.

Invertebrate Zoology 14: 32-44.

 

Bernardo-Garcia FJ,  Humberg TH, Fritsch C & Sprecher SG (2016). 

Successive requirement of Glass and Hazy for photoreceptor specification and maintenance in Drosophila. 

Fly 11:2, 112-120 (link).

 

Humberg TH & Sprecher SG &  (2017). 

Age- and wavelength-dependency of Drosophila larval phototaxis and behavioral responses to natural lighting conditions. 

Front. Behav. Neurosci. 11: article 66 (link).

 

2016

 

van Giesen L, Neagu-Maier GL, Kwon JY & Sprecher SG (2016). 

A microfluidics-based method for measuring neuronal activity in Drosophila chemosensory neurons.

Nature Protocols 11: 2389-2400. (link)

 

Choi J, van Giesen L, Choi MS, Kang K, Sprecher SG & Kwon JY (2016). 

A pair of pharyngeal gustatory receptor neurons regulates caffeine-dpendent ingestion in Drosophila larvae. 

Front. Cell. Neurosci. 10: #181. doi: 10.3389/fncel.2016.00181. (link)

 

Spühler IA, Conley GM, Scheffold F & Sprecher SG (2016). 

Super resolution imaging of genetically labeled synapses in Drosophila brain tissue. 

Front. Cell. Neurosci. 10: 142. doi: 10.3389/fncel.2016.00142. (link)

 

Bernardo-Garcia FJ, Fritsch C & Sprecher SG (2016). 

The transcription factor glass links eye field specification with photoreceptor differentiation in Drosophila.

Development 143: 1413-1423. (link)

 

van Giesen L, Hernandez-Nunez L, Delasoie-Baranek S, Colombo M, Renaud P, Bruggmann R, Benton R, Samuel ADT & Sprecher SG (2016). 

Multimodal stimulus coding by a gustatory sensory neuron in Drosophila larvae.

Nature Communications 7: # 10687 (doi:10.1038/ncomms10687).

 

Mishra AK,  Bargmann BOR, Tsachaki M, Fritsch C & Sprecher SG (2016).

Functional genomics identifies Regulators of the phototransduction machinery in the drosophila larval eye and adult ocelli.

Developmental Biology 410: 164-177.

 

2015


Sprecher SG, Bernardo-Garcia FJ, van Giesen L, Hartenstein V, Reichert H, Neves R, Bailly X, Martinez P & Brauchle M (2015). 
Functional brain regeneration in the acoel worm Symsagittifera roscoffensis.

Biology Open 4: 1688-1695 (online doi:10.1242/bio.014266). 

 

Guillermin O, Perruchoud B, Sprecher SG & Egger B (2015). 

Characterization of tailless functions during Drosophila optic lobe formation.

Developmental Biology (doi: 10.1016/j.ydbio.2015.06.011. Epub 2015 Jun 23).

 

Bressan JM, Benz M, Oettler J, Heinze J, Hartenstein V, Sprecher SG (2015). 

A map of brain neuropils and fiber systems in the ant Cardiocondyla obscurior. 

Front Neuroanat. Feb 4;8:166. doi: 10.3389/fnana.2014.00166.

 

2014 

 

Klein M, Afonso B, Ashley J. Vonner AJ, Hernandez-Nunez L, Berck M, Tabone CJ, Kane EA, Pieribone VA, Nitabach MN, Cardona A, Zlatic M, Sprecher SG, Gershow M, Garrity PA & Samuel ADT (2014).

Sensory determinants of behavioral dynamics in Drosophila thermotaxis.

Proc Natl Acad Sci (USA)112: E220-E229..

 

Brauchle M, Hansen S, Caussinus E, Lenard A, Ochoa-Espinosa A, Oliver Scholz, Sprecher SG, Plückthun A & Affolter M (2014). 

Protein interference applications in cellular and developmental biology using DARPins that recognize GFP and mCherry. 

Biology Open BIO201410041 (online doi:10.1242/bio.201410041).

 

Pauls D, von Essen A, Lyutova R, van Giesen L, Rosner R, Wegener C & Sprecher SG (2014).

Potency of Transgenic Effectors for Neurogenetic Manipulation in Drosophila Larvae.

Genetics 199: 25-U430. 

 

Diegelmann S & Sprecher SG (2014). 

An epigenetic way to forget those painful memories.

Trends in Neurosciences 37(6): 245-246.

 

Sprecher SG (2014). Brain Development: methods and protocols. ISBN 9781627036542, Humana Press, New York 

 

2013

 

Farca-Luna AJ & Sprecher SG (2013).

Plasticity in the Drosophila laraval visual system.

Frontiers in Cellular Neuroscience 7:105, doi: 10.3389/fncel.2013.00105.

 

Bürgy-Roukala E, Miellet S, Mishra AK & Sprecher SG (2013).

Early eye development: specification and determination. In Molecular genetics of axial patterning, growth and disease in the Drosophila eye (eds Singh A & Kango-Singh M), pp 1-36, DOI: 10.10.1007/978-1-4614-8232-1_1, Springer, New York.  

 

Mishra AK, Tsachaki M, Rister J, Ng J, Celik A & Sprecher SG (2013).

Binary cell fate decisions and fate transformation in the Drosophila larval eye. 

PLoS Genetics 9(12):e1004027 (DOI:10.1371/journal.pgen.1004027).

 

Kane EA, Gershow M, Afonso B, Larderet I, Klein M, Carter AR, de Bivort BL, Sprecher SG, Samuel AD. (2013). 

Sensorimotor structure of Drosophila larva phototaxis. 

Proc Natl Acad Sci (USA) 110: E3868-E3877, doi:10.1073/pnas.1215295110.

 

De Vaux V, Pfefferli C, Passannante M, Belhaj K, von Essen A, Sprecher SG, Müller F, Wicky C. (2013).

The C. elegans LET-418/Mi2 plays a conserved role in lifespan regulation. 

Ageing Cell 12: 1012-1020.

 

Egger B, Van Giesen L, Moraru M & Sprecher SG (2013). 

In vitro imaging of primary neural cell culture from Drosophila.

Nature Protocols 8: 958-965.

 

Farca Luna A, von Essen AM, Widmer Y & Sprecher SG (2012), 

Light preference assay to study innate and circadian regulated photobehavior in Drosophilalarvae.

 J. Vis. Exp. (74), e50237, doi:10.3791/50237 (2013).  

 

2012 

 

Louis M, Phillips M, Lopez-Matas M & Sprecher S (2012).
Behavioral analysis of navigation behaviors in the Drosophila larva in "Neuromethods" Vol 69, 163-199, ed Hassan BA, Springer.
 
Huser A, Rohwedder A, Maiolo EM, Selcho M, Pauls D, von Essen AM, Gupta T, Sprecher SG, Birman S, Riemensperger T, Stocker RF and Thum AS (2012).
The Serotonergic Central Nervous System of the Drosophila Larva: Anatomy and Behavioral Function. 
PLoS ONE 7(10): e47518. doi:10.1371/journal.pone.0047518.
 
Moraru M, Egger B, Bao DB and Sprecher SG (2012). 
Analysis of cell identity, morphology, apoptosis and mitotic activity in a primary neural cell culture system in Drosophila. 
Neural Development 7:14 (online).
 
Keene AC & Sprecher SG (2012). Seeing the light: Photobehavior in fruit fly larvae. 
Trends in Neurosciences 35: 104-110.
 
Sprecher SG (2012). "Drosophila neural development" 
In: eLS,  John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0000791.pub2 .
Tsachaki M & Sprecher SG (2012). 
Genetic and developmental mechanisms underlying the formation of the Drosophila compound eye. 
Developmental Dynamics 241:40-56.

 

2011 

 

Von Essen AHJ, Pauls D, Thum AS & Sprecher SG (2011) 
Capacity of visual classical conditioning in Drosophila larvae. 
Behavioral Neuroscience 125: 921-929. 
 
Vasiliauskas D, Mazzoni EO, Sprecher SG, Brodetskiy K, Johnston RJ, Lidder P, Vogt N, Celik A & Desplan C (2011).
Feedback from Rhodopsin protein controls rhodopsin exclusion in Drosophila photoreceptors.
Nature 479: 108-112.
 
Sprecher SG, Cardona A & Hartenstein V (2011).
The Drosophila larval visual system: High-resolution analysis of a simple visual neuropil.
Developmental Biology 358: 33-43.
 
Keene A, Mazzoni E, Zhen J, Younger M, Yamaguchi S, Blau J, Desplan C & Sprecher SG (2011).
Distinct visual pathways mediate Drosophila larval light avoidance and circadian clock entrainment.
 
Diaz NN & Sprecher SG (2011).
Photoreceptors: unconventional ways of seeing.
Current Biology 21: R25-27.  

 

2009 

 

Sprecher SG & Desplan C (2009).
"Development of the Drosophila eye, from precursor specification to terminal differentiation". 
In "Animal models for eye research" eds Tsonis PA & Wittbrodt J, Elsevier. 
 
Sprecher SG (2009).
"Evolution of the brain in Urbilateria".
In "Encyclopedic Reference of Neuroscience" eds  Binder MD, Hirsch CM & Nobutaka H, Springer. 
 
Sprecher S & Desplan C (2009).
Plasticity of terminally differentiated neurons by switching rhodopsin expression.
J Neurogenetics 23: S22. 
 

2008 

 
Sprecher SG & Desplan C (2008).
Switch of rhodopsin expression in terminally differentiated Drosophila sensory neurons. 
Nature 454: 33-537

 

2007 

 

Sprecher SG, Pichaud F & Desplan C (2007).
Adult and larval photoreceptors use different mechanisms to specify the same Rhodopsin fates 
Genes and Development 21: 2182-2195.
 
Sprecher SG, Reichert H and Hartenstein V (2007).
Gene expression patterns in primary neuronal clusters of the Drosophila embryonic brain. 
Gene Expression Patterns 7: 584-595.

 

2006 

 

Sprecher SG, Urbach R, Technau GM, Rijli FM, Reichert H & Hirth F (2006). 
The columnar gene vnd is required for tritocerebral neuromere formation during embryonic brain development of Drosophila. 
Development 133: 4331-4339.
 
Sprecher SG & Hirth F (2006).
The dorsoventral patterning gene msh is required for tritocerebral neuromere formation during embryonic brain development of Drosophila.
Developmental Dynamics 235: 2920-2929.
 
Meier S, Sprecher SG, Reichert H & Hirth F (2006). Ventral veins lacking is required for specification of the tritocerebrum in embryonic brain development of Drosophila. Mechanisms of Development 123: 76-83.

 

2004 

 

Sprecher SG, Müller M, Kammermeier L, Miller D, Kaufman TC, Reichert H & Hirth F (2004).

Hox gene cross-regulatory interactions in the embryonic brain of Drosophila. 

Mechanisms of Development 121: 527-536.

 

2003  

 

Sprecher SG, Galle S & Reichert H (2003).

Substrate specificity and juvenile Faviid predominance of coral colonization at the Maldive Islands following the 1998 bleaching event. 

Coral Reefs 22: 130-132.

 

Sprecher SG & Reichert H (2003).

The urbilaterian brain: developmental insights into the evolutionary origin of the brain in insects and vertebrates.

Arthropod Struct Dev, 32: 141-156.